If you are taking a Proton Pump Inhibitor (PPI) such as the following: Nexium, Protonix, Prevacid, Aciphex, or Prilosec (omeprazole), it is important to take your medicines 30 minutes-1 hour before meals. Most of these medicines are given twice-a-day, so that will mean taking a pill before breakfast and dinner. The medicine is absorbed better if taken this way.